Solubility and solution thermodynamics of 2,3,4,5-tetrabromothiophene in (ethanol + tetrahydrofuran) binary solvent mixtures

• The solubility of tetrabromothiophene in binary solvent mixture was investigated.
• The two variants of the CNIBS/R–K equation and the Jouyban–Acree equation.
• The solution process of tetrabromothiophene in binary solvent mixture was endothermic.

The solubility of 2,3,4,5-tetrabromothiophene in (ethanol + tetrahydrofuran) binary solvent mixtures was measured within the temperature range from (278.15 to 322.15) K. The solubility increases with the rise of temperature, while it decreases with increasing ethanol content at constant temperature. The experimental data were fitted using the two variants of the combined nearly ideal binary solvent/Redlich–Kister (CNIBS/R–K) equation and the Jouyban–Acree equation, respectively. All the three equations were proven to give good representations of the experimental values. Computational results showed that the variant two of CNIBS/R–K equation was superior to the other two equations. The thermodynamic properties of the solution process, including the Gibbs free energy, enthalpy, and entropy, were calculated by the van’t Hoff analysis. The values of both the enthalpy change and the standard molar Gibbs free energy change of solution were positive, which indicated that the process was endothermic.