Electro-oxidation of nimesulide at 5% barium-doped zinc oxide nanoparticle modified glassy carbon electrode

• Electrochemical behavior of nimesulide was investigated for first time at 5% Ba-doped ZnO nanoparticle modified GCE
• The electrode process was irreversible and diffusion controlled
• Probable electrochemical mechanism was proposed
• The LOD and LOQ values were calculated to be 1.79 nM and 5.9 nM, respectively, and better compared to other reported methods
• Proposed method was applied to nimesulide determination in pharmaceutical and spiked human urine samples

Development of methods for the detection of an analyte at low concentration with less time for analysis has become a prior point of interest to every analyst. In reflection of this fact, an effort has been made to synthesize 5% barium doped zinc oxide nanoparticles and was characterized by using XRD, EDX, SEM, and TEM. Further, 5% barium doped zinc oxide nanoparticle modified glassy carbon electrode was used for investigating the electro-chemical behavior of nimesulide. Voltammograms obtained in a range of 3.0–11.2 (I = 0.2 M) pH had a maximum peak current at pH 7.0. Various physio-chemical parameters such as, process on the surface of the electrode, which was found to be diffusion controlled, heterogeneous rate constant, number of electrons transferred and charge transfer coefficient were estimated. Further, a method for nimesulide determination in a linear range of 1.0 × 10− 5 to 1.0 × 10− 7 M with LOD 1.794 nM was proposed. This technique was later used for analytical application.

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