کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2181841 1095413 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Temporal and tissue specific gene expression patterns of the zebrafish kinesin-1 heavy chain family, kif5s, during development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Temporal and tissue specific gene expression patterns of the zebrafish kinesin-1 heavy chain family, kif5s, during development
چکیده انگلیسی


• Zebrafish Kif5s are phylogenetically related to their mammalian orthologs.
• Only kif5Ba, kif5Bb, and kif5C transcripts are maternally provided.
• kif5Aa, kif5Ab, and kif5C transcripts are restricted to neural tissues of late embryos.
• Ubiquitous kif5Bs become enriched in the larval brain and digestive tract.
• kif5s show distinct expression domains in the zebrafish larval retina.

Homo- and heterodimers of Kif5 proteins form the motor domain of Kinesin-1, a major plus-end directed microtubule motor. Kif5s have been implicated in the intracellular transport of organelles, vesicles, proteins, and RNAs in many cell types. There are three mammalian KIF5s. KIF5A and KIF5C proteins are strictly neural in mouse whereas, KIF5B is ubiquitously expressed. Mouse knockouts indicate crucial roles for KIF5 in development and human mutations in KIF5A lead to the neurodegenerative disease Hereditary Spastic Paraplegia. However, the developmental functions and the extent to which individual kif5 functions overlap have not been elucidated. Zebrafish possess five kif5 genes: kif5Aa, kif5Ab, kif5Ba, kif5Bb, and kif5C. Here we report their tissue specific expression patterns in embryonic and larval stages. Specifically, we find that kif5As are strictly zygotic and exhibit neural-specific expression. In contrast, kif5Bs exhibit strong maternal contribution and are ubiquitously expressed. Lastly, kif5C exhibits weak maternal expression followed by enrichment in neural populations. In addition, kif5s show distinct expression domains in the larval retina.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Expression Patterns - Volume 13, Issue 7, October 2013, Pages 271–279
نویسندگان
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