Nitrogen and sulfur dual-doped graphene for glucose biosensor application

• N, S dual-doped graphene (NS-G) was applied for glucose sensing.
• The synergetic effect of N and S atoms improved the electrocatalytic properties.
• NS-G provided more active sites for oxygen absorption and glucose oxidation.
• NS-G outperformed the single-doped N-G for glucose sensing.

This work demonstrated the potential application of the N, S dual-doped graphene (NS-G) as a novel glucose oxidase (GOD) platform for glucose sensing. The NS-G was prepared by a simple two-step solvothermal method using urea as the N precursor and benzyl disulfide as the S precursor. The morphology and structure of as-prepared NS-G were characterized, and its electrochemical properties were examined. In comparison with the single N-doped graphene (N-G) based sensor, the dual-doped NS-G modified sensor showed significantly improved electrochemical sensing performances for glucose detection due to the synergistic effect of the coupling interactions between N and S heteroatoms that were responsible for the superior electrocatalytic properties. This study suggested that dual-doped graphene with two heteroatoms could be an effective way to greatly improve the electrochemical sensing performances of graphene-based GOD glucose biosensor.

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