Electrochemical behavior of ferrocene-terminated hyperbranched polyurethane and its directly electrochemical sensing to glucose and ATP2−

• A novel carbamate-containing organometallic hyperbranched polymer (HBPU-Fc).
• HBPU-Fc showed special quasi-reversible electrochemical behavior.
• Application of HBPU-Fc in directly electrochemical sensing to glucose was investigated.
• HBPU-Fc exhibits significant response to anions ATP2− (Adenosine-5′ Triphosphate).
• The interaction model of HBPU-Fc with glucose and ATP2− are also presented.

We designed a series of novel carbamate-containing organometallic hyperbranched polymers, namely, generation 1 to generation 3 of ferrocene-terminated hyperbranched polyurethane (HBPU-Fc). We report here in full details on synthesis, characterization, and redox behaviors of HBPU-Fcs, which are expected to serve as supramolecular receptors for direct sensing glucose and Adenosine Triphosphate (ATP). The synthetic route involved the construction of the hyperbranched polymer fragments. The different redox behaviors of the new metallic hyperbranched polyurethane and its film immobilized on electrode were studied by cyclic voltammetry and differential pulse voltammetry (DPV). The application of HBPU-Fc in direct electrochemical sensing to glucose and ATP anion (Adenosine-5′ Triphosphate, ATP2−) were carried out using HBPU-Fc as receptor. HBPU-Fc exhibited significant responses to both anion ATP2− and neutral molecule glucose. Some structural recognitions and supramolecular interaction of HBPU-Fc with glucose or with ATP2− changed the course of electron transfer in ferrocene/ferrocenium redox couple. This finding makes HBPU-Fc a promising candidate for biosensing material.

A novel topological structure carbamate-containing organometallic hyperbranched polymer–ferrocene-terminated hyperbranched polyurethane (HBPU-Fc) and its film electrode exhibit special electrochemical properties relative to monomerferrocene. The application of HBPU-Fc in directly electrochemical sensing to glucose and ATP (Adenosine-5′ Triphosphate, ATP2−) were carried out with HBPU-Fc as receptor. HBPU-Fc shows significant response to both anion ATP2− and neutral molecule glucose. Some structural recognition and supramolecular interaction between HBPU-Fc and glucose as well as ATP2− changed the course of electron transfer in ferrocene/ferrocenium redox couple. This finding makes HBPU-Fc a promising candidate for biosensing material.Figure optionsDownload as PowerPoint slide