کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
21907 | 43242 | 2010 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Catechol derivatives inhibit the fibril formation of amyloid-β peptides Catechol derivatives inhibit the fibril formation of amyloid-β peptides](/preview/png/21907.png)
The inhibition of fibril formation of amyloid β proteins (Aβ) would be attractive therapeutic targets for the treatment of Alzheimer's disease (AD). Dopamine (DA) and other catechol derivatives were used as inhibitory factors for Aβ fibril formation. The fibril formation of Aβ was monitored by Thioflavin T fluorescence, a transmission electron microscopy (TEM) and a total internal reflection fluorescence microscopy (TIRFM). Catechol and its derivatives showed the dose-dependent inhibitory effects on the spontaneous Aβ fibril formation. The inhibitory activity depended on the chemical structure of catechol derivatives both in the presence and absence of the liposome a model of biomembrane. Formation of catechol quinone-conjugated-Aβ adduct by a Schiff-base is a key step for the inhibition effect of Aβ fibril formation.
Journal: Journal of Bioscience and Bioengineering - Volume 109, Issue 6, June 2010, Pages 629–634