کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
219359 | 463269 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A highly sensitive method for determination of β-blocker drugs using a Nafion-coated glassy carbon electrode A highly sensitive method for determination of β-blocker drugs using a Nafion-coated glassy carbon electrode](/preview/png/219359.png)
The electrochemical response of bisoprolol fumarate (BF) and propranolol hydrochloride (PR) is significantly enhanced by immobilization of a Nafion film on the surface of the glassy carbon electrode. The positively charged drug molecules were accumulated in 0.1 mol L−1 sulfuric acid solution at a potential of +0.6 V for 120 s, and then determined by square-wave anodic voltammetry. The enhancement mechanism and effect factors such as pH value, mass of Nafion, accumulation potential and pre-concentration time, were explored. The peak current is proportional to the concentration in the range from 5 × 10−8 to 5 × 10−7 mol L−1 for BF and from 8 × 10−8 to 6 × 10−7 mol L−1 for PR, with the sensitivities of 1.49 × 108 and 2.47 × 107 μA mol−1 L, respectively. The modified electrode was used to determine both β-blockers in commercial tablets. The quantification of BF in urine samples with no prior extraction was carried out after selective accumulation at the electrode surface under stirring. Together with low cost and ease preparation, the modified electrode is a promising sensor in electroanalysis, not only for the detection of BF and PR, but also for other β-blocker drugs.
► Sensitive method for determination of bisoprolol and propranolol.
► Nafion coated glassy carbon electrode.
► Simple approach adopted for modification of electrode surface.
► Quantification of drugs in pharmaceutical products and urine samples.
► Modified electrode as promising sensor in electroanalysis of other β-blocker drugs.
Journal: Journal of Electroanalytical Chemistry - Volume 663, Issue 2, 15 December 2011, Pages 72–78