Granulomatous invasive fungal rhinosinusitis extending into the pterygopalatine fossa and orbital floor: A case report

Invasive fungal rhinosinusitis is a rare and life-threatening disease. Granulomatous invasive fungal rhinosinusitis has a time course exceeding 12 weeks, and the destruction of bone progresses slowly. This disease has been reported primarily in Sudan, India, Pakistan, and the USA; however, it is very rare in Korea. In this study, we present the case of a 69-year-old man with granulomatous invasive fungal rhinosinusitis. He was successfully treated with a combination of surgery and itraconazole.

► Granulomatous invasive fungal rhinosinusitis is very rare in Northeast Asia.
► This disease develops in immunocompetent patients.
► Histological characteristic of this disease is tissue invasion by Aspergillus with the formation of granuloma and fibrosis.
► We treat this disease successfully with surgery and antifungal agents (itraconazole) preserving the vision of the patient.