کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2432841 1106807 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The induction of nitric oxide response of carp macrophages by transferrin is influenced by the allelic diversity of the molecule
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم آبزیان
پیش نمایش صفحه اول مقاله
The induction of nitric oxide response of carp macrophages by transferrin is influenced by the allelic diversity of the molecule
چکیده انگلیسی

The central role of transferrin (Tf) as an iron transporting protein has been extended by observations that modified versions of Tf also participate in the regulation of innate immunity. We report on the isolation of two carp Tf proteins (alleles D and G) to purity using rivanol precipitation and ion-exchange chromatography, and describe the activation of head kidney-derived carp macrophages by cleaved Tf. We demonstrate the superiority of the D-type over the G-type Tf in inducing nitric oxide (NO) and confirm previous observations that full-length Tf cannot induce NO in fish macrophages. We believe that cleaved Tf fragments should be considered to be “alarmins”. We discuss the possibility that parasites such as Trypanoplasma borreli cleave Tf and use Tf fragments to their advantage by modulating the NO induction in carp macrophages.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fish & Shellfish Immunology - Volume 26, Issue 4, April 2009, Pages 632–638
نویسندگان
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