کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2435723 | 1107093 | 2007 | 9 صفحه PDF | دانلود رایگان |
Several novel peptides with demonstrated antihypertensive activity have been identified in milk fermented with Enterococcus faecalis CECT 5727. Two of the identified peptides, corresponding to β-casein f(133–138) (LHLPLP) and β-casein f(58–76) (LVYPFPGPIPNSLPQNIPP), showed angiotensin converting enzyme-inhibitory (ACEI) activity (IC50) values as low as 5 μm. These peptides demonstrated antihypertensive activity when they were orally administered to spontaneously hypertensive rats. In particular, β-casein f(133–138), yielded a significant antihypertensive effect in these animals. The maximal decreases in systolic blood pressure (21.87±4.51 mmHg, n=8n=8) and diastolic blood pressure (28.5±3.20 mmHg, n=8n=8) were observed 4 and 2 h, respectively, after the administration of 2 mg kg−1 of this peptide. The presence of these antihypertensive peptides in fermented milk prepared with other selected strains of E. faecalis (CECT 5728, 5826 and 5827) was confirmed by HPLC-MS.
Journal: International Dairy Journal - Volume 17, Issue 1, January 2007, Pages 33–41