Identification of a polypeptide containing Tudor and staphyloccocal nuclease-like domains as the sequence-specific binding protein to the upstream regulatory element 1 of Entamoeba histolytica

► An Entamoeba histolytica protein with Tudor and SNase domains binds to the regulatory element URE1. ► EhURE1BP has one Tudor and five SNase domains. ► The C-terminus of EhURE1BP contains the DNA-binding domain.