کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2438413 1107714 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vaccines for the Elderly: The Quest for the Ideal Animal Model
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Vaccines for the Elderly: The Quest for the Ideal Animal Model
چکیده انگلیسی

SummaryA decline in protective immune responses following vaccination is one of the main features of immunosenescence. Improved vaccine candidates for elderly adults are thus urgently needed. For scientific and regulatory requirements, such new vaccines must first be evaluated at the preclinical level, and there is a continuing quest for the ideal animal model with which to perform such studies. The main advantages and limitations of murine models, those most commonly used for human vaccine research, and of large animal models are reviewed and discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Comparative Pathology - Volume 142, Supplement 1, January 2010, Pages S70–S73
نویسندگان
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