کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2440034 | 1108110 | 2008 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A Meta-Analysis of the Impact of Monensin in Lactating Dairy Cattle. Part 1. Metabolic Effects
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A Meta-Analysis of the Impact of Monensin in Lactating Dairy Cattle. Part 1. Metabolic Effects A Meta-Analysis of the Impact of Monensin in Lactating Dairy Cattle. Part 1. Metabolic Effects](/preview/png/2440034.png)
چکیده انگلیسی
A meta-analysis of the impact of monensin on metabolism of dairy cattle was conducted following a search of the literature. A total of 59 studies with monensin feeding in dairy cattle were identified in which 30 papers and 45 trials contained metabolic data. The β-hydroxybutyrate (BHBA) data were obtained from over 4,000 cows and 115 trial sites. Data for each trial were extracted and analyzed using meta-analysis software in Stata. Estimated effect sizes of monensin were calculated on blood concentrations of BHBA, acetoacetate, nonesterified fatty acids (NEFA), glucose, cholesterol, urea, calcium, insulin, and milk urea. Monensin use in lactating dairy cattle significantly reduced blood concentrations of BHBA 13%, acetoacetate 14%, and NEFA 7%. Monensin increased glucose 3% and urea 6%. Monensin had no significant effect on cholesterol, calcium, milk urea, or insulin. Heterogeneity was significant for BHBA and cholesterol [I2 (measure of variation beyond chance) = 37 and 54%, respectively]; therefore, random effects models were used for those analytes. Publication bias existed with the monensin effect on BHBA, with a tendency for studies to be published if there was a significant reduction in this ketone. Meta-regression analysis of the effect sizes obtained from the metabolic data showed that method of delivery, timing of administration, stage of lactation, and diet were influential in modifying effect size of monensin treatment. Use of top dress or delivery via a controlled release capsule reduced the magnitude of effect on BHBA (coefficient +0.353); however, top dress use compared with controlled release capsule or total mixed ration enhanced the monensin effect on glucose (coefficient +0.296). There was a greater impact with monensin on reducing BHBA in early lactation (coefficient â0.151) and in pasture-based trials (coefficient â0.194). Use of monensin in both the pre- and postcalving periods was associated with an enhanced impact on NEFA (coefficient â0.254). Monensin had less impact on serum glucose in the pre-calving time period (coefficient â0.237). These findings demonstrate an improvement in the energy metabolism of dairy cows supplemented with monensin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dairy Science - Volume 91, Issue 4, April 2008, Pages 1334-1346
Journal: Journal of Dairy Science - Volume 91, Issue 4, April 2008, Pages 1334-1346
نویسندگان
T.F. Duffield, A.R. Rabiee, I.J. Lean,