کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2454826 1110495 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oxidative stress in mice treated with antileishmanial meglumine antimoniate
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Oxidative stress in mice treated with antileishmanial meglumine antimoniate
چکیده انگلیسی

In order to improve the understanding of the toxicity of pentavalent antimony (SbV), we investigated the acute effects of meglumine antimoniate (MA) on the oxidative stress in heart, liver, kidney, spleen and brain tissue of mice. Levels of lipoperoxidation and protein carbonylation were measured to evaluate the oxidative status, whereas superoxide dismutase/catalase activity and glutathione levels were recorded to examine the antioxidative status. We observed that MA caused significant protein carbonylation in the heart, spleen and brain tissue. Increased lipoperoxidation was found in the liver and brain tissue. An imbalance between superoxide dismutase and catalase activities could be observed in heart, liver, spleen and brain tissue. Our results suggest that MA causes oxidative stress in several vital organs of mice. This indicates that the production of highly reactive oxygen and nitrogen species induced by MA might be involved in some of its toxic adverse effects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 95, Issue 3, December 2013, Pages 1134–1141
نویسندگان
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