کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2455027 1110503 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Toll-like receptor activation and expression in bovine alpha-herpesvirus infections
ترجمه فارسی عنوان
فعال شدن و بیان گیرنده های پولی در عفونت های آلفا هرپس ویروس گاو
کلمات کلیدی
گیرنده سفارشی، ویروس هرپس گاو، آگونیست، الگوهای بیان
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی

The involvement of Toll-like receptors (TLRs) in bovine herpesvirus types 1 (BoHV-1) and 5 (BoHV-5) infections has not been analyzed. In this study, the role of TLR signaling on virus replication was investigated. Blood leukocytes consistently express TLRs. Thus, our approach was to study in vitro the effects of agonist stimulation of TLRs expressed by peripheral blood leukocytes on BoHV-1 and BoHV-5 replication. Furthermore, the patterns of TLRs 3, 7–9 expression on virus-infected-bovine leukocytes were analyzed. Only Imiquimod (TLR7/8 agonist) showed anti-viral activity on infected MDBK cells. This is the first evidence that the timely activation of TLR7/8 signaling is effective in impairing BoHV-1 and 5 replication, thereby providing an experimental indication that Imiquimod may be a promising immune modulator. This work describes, for the first time, the expression patterns of TLRs in BoHV-1- or BoHV-5-infected-bovine leukocytes, suggesting the involvement of TLR7 and TLR9 in the recognition of these viruses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 96, Issue 1, February 2014, Pages 196–203
نویسندگان
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