کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2455606 | 1110516 | 2011 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Comparative analysis of the early transcriptome of Brucella abortus – Infected monocyte-derived macrophages from cattle naturally resistant or susceptible to brucellosis Comparative analysis of the early transcriptome of Brucella abortus – Infected monocyte-derived macrophages from cattle naturally resistant or susceptible to brucellosis](/preview/png/2455606.png)
Brucellosis is a worldwide zoonotic infectious disease that has a significant economic impact on animal production and human public health. We characterized the gene expression profile of B. abortus-infected monocyte-derived macrophages (MDMs) from naïve cattle naturally resistant (R) or susceptible (S) to brucellosis using a cDNA microarray technology. Our data indicate that (1) B. abortus induced a slightly increased genome activation in R MDMs and a down-regulated transcriptome in S MDMs, during the onset of infection, (2) R MDMs had the ability to mount a type 1 immune response against B. abortus infection which was impaired in S cells, and (3) the host cell activity was not altered after 12 h post-B. abortus infection in R MDMs while the cell cycle was largely arrested in infected S MDMs at 12 h p.i. These results contribute to an improved understanding of how host responses may be manipulated to prevent infection by brucellae.
Journal: Research in Veterinary Science - Volume 91, Issue 1, August 2011, Pages 40–51