کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2474461 1113141 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparison of drug release from liquid crystalline monoolein dispersions and solid lipid nanoparticles using a flow cytometric technique
ترجمه فارسی عنوان
مقایسه آزادی دارو از پراکندگی مونولین مایع بلورین و نانوذرات لیپید جامد با استفاده از تکنیک جریان سیاتومتر
کلمات کلیدی
ذرات کوبی، انتشار مواد مخدر، انتقال مواد مخدر، تکنیک جریان سیاتومتر، قطرات امولسیونی، نانوذرات لیپید جامد، پورفیرین
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

Colloidal lipid particles such as solid lipid nanoparticles and liquid crystalline nanoparticles have great opportunities as drug carriers especially for lipophilic drugs intended for intravenous administration. In order to evaluate drug release from these nanoparticles and determine their behavior after administration, emulsion droplets were used as a lipophilic compartment to which the transfer of a model drug was measured. The detection of the model drug transferred from monoolein cubic particles and trimyristin solid lipid nanoparticles into emulsion droplets was performed using a flow cytometric technique. A higher rate and amount of porphyrin transfer from the solid lipid nanoparticles compared to the monoolein cubic particles was observed. This difference might be attributed to the formation of a highly ordered particle which leads to the expulsion of drug to the surface of the crystalline particle. Furthermore, the sponge-like structure of the monoolein cubic particles decreases the rate and amount of drug transferred. In conclusion, the flow cytometric technique is a suitable technique to study drug transfer from these carriers to large lipophilic acceptors. Monoolein cubic particles with their unique structure can be used successfully as a drug carrier with slow drug release compared with trimyristin nanoparticles.

Compared to commonly applied release methods, the transfer to a lipophilic acceptor compartment is better than the commonly applied release methods. The flow cytometric technique is a suitable technique to study the transfer of porphyrin from the different drug carriers to the lipophilic acceptor as it mimics lipid compartments in the body.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Pharmaceutica Sinica B - Volume 6, Issue 2, March 2016, Pages 163–169
نویسندگان
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