کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2474492 1113143 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Three new lignan glucosides from the roots of Scutellaria baicalensis
ترجمه فارسی عنوان
سه گلوکوزید لیگنان جدید از ریشه Scutellaria baicalensis
کلمات کلیدی
Scutellaria baicalensis؛ ریشه ها؛ Labiatae؛ گلوکوزید لیگنان؛ Baicalensinosides A-C؛ 3،4-دیابینسیل تترا هیدرو فوران؛ فعال فعال osteoprotegerin؛ فعالیت ضد پوکی استخوان
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

Three new lignan glucosides, baicalensinosides A–C (1–3), were isolated from the roots of Scutellaria baicalensis. The structural elucidation was achieved by in-depth spectroscopic examinations and qualitative chemical test. Structurally, these compounds belong to the 3,4-dibenzyltetrahydrofuran-type lignan glycoside with a mono-hydroxyl substitution at the 7′-position of benzylidene group on the numbering system of lignans being one of their shared critical features. The anti-osteoporotic activity of the isolated compounds was assessed in an in vitro osteoprotegerin (OPG) transcriptional activity assay using dual luciferase reporter detection. At 10 μmol/L, compounds 1–3 increased the relative activating ratio of OPG transcription to 1.83, 0.84 and 0.98 times that of the control group, respectively.

Three new lignan glucosides, baicalensinosides A–C (1–3), were isolated from the roots of Scutellaria baicalensis. Structurally, these compounds belong to the 3,4-dibenzyltetrahydrofuran-type lignan glycoside with a mono-hydroxyl substitution at the 7′-position of benzylidene group on the numbering system of lignans being one of their shared critical features. At 10 μmol/L, compounds 1–3 increased the relative activating ratio of osteoprotein (OPG) transcription to 1.83, 0.84 and 0.98 times that of the control group, respectively.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Pharmaceutica Sinica B - Volume 6, Issue 3, May 2016, Pages 229–233
نویسندگان
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