کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2474528 1113146 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanocarrier-mediated co-delivery of chemotherapeutic drugs and gene agents for cancer treatment
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Nanocarrier-mediated co-delivery of chemotherapeutic drugs and gene agents for cancer treatment
چکیده انگلیسی

The efficacy of chemotherapeutic drug in cancer treatment is often hampered by drug resistance of tumor cells, which is usually caused by abnormal gene expression. RNA interference mediated by siRNA and miRNA can selectively knock down the carcinogenic genes by targeting specific mRNAs. Therefore, combining chemotherapeutic drugs with gene agents could be a promising strategy for cancer therapy. Due to poor stability and solubility associated with gene agents and drugs, suitable protective carriers are needed and have been widely researched for the co-delivery. In this review, we summarize the most commonly used nanocarriers for co-delivery of chemotherapeutic drugs and gene agents, as well as the advances in co-delivery systems.

Combining chemotherapeutic drugs with gene agents could be a promising strategy for cancer therapy. Four major types of nanocarriers to co-delivery gene and chemotherapeutic drugs were reviewed, including (a) cationic liposome, (b) micelle system, (c) dendrimer system, and (d) supramolecular system.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Pharmaceutica Sinica B - Volume 5, Issue 3, May 2015, Pages 169–175
نویسندگان
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