کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2474706 1113158 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Doxorubicin-loaded zein in situ gel for interstitial chemotherapy of colorectal cancer
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Doxorubicin-loaded zein in situ gel for interstitial chemotherapy of colorectal cancer
چکیده انگلیسی

The aim of this research was to evaluate doxorubicin (DOX)-loaded zein in situ gels, a new drug delivery system in which a liquid state drug can be transformed into semi-solid after intratumoral injection. In vitro release of DOX-loaded zein was investigated and the pharmacokinetics, biodistribution and therapeutic efficacy of these DOX-loaded zein formulations were investigated using BALB/c nude tumor-bearing mice. In vitro release of DOX from the gels extended up to 7 days. Efficient accumulation of DOX in the tumor with lower drug concentration in blood and normal organs was obtained resulting in effective inhibition of tumor growth and fewer off-target side effects. In conclusion, a DOX-loaded in situ gel was developed with sustained release, enhanced anti-cancer efficacy for colorectal cancer in vivo, and especially with reduced off-target side effects.

Graphical AbstractA new sustained release drug delivery system of doxorubicin-loaded Zein in situ gels was successfully developed with enhanced anti-cancer efficacy for colorectal cancer in vivo and especially with reduced off-target side effects.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Pharmaceutica Sinica B - Volume 2, Issue 6, December 2012, Pages 610–614
نویسندگان
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