کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2474854 1113168 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Radical-scavenging activities of marine-derived xyloketals and related chromanes
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Radical-scavenging activities of marine-derived xyloketals and related chromanes
چکیده انگلیسی

Xyloketals, a new type of antioxidants from a marine mangrove fungus, have potential pharmacological properties. In this paper, the radical-scavenging activities of a series of synthetic xyloketals and related chromanes toward 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) were evaluated by absorption spectrometry. One of the compounds (compound 10) displayed significant antioxidative action against DPPH and ABTS. A structure-activity analysis showed that the reactive sites on these compounds correlated with a hydroxy-group and also with ketal or aromatic H substituents. Based in part on a density functional theory (DFT) calculation of compound 10, the antioxidant mechanism of this chromane was deduced as a possible radical-scavenging mechanism by a sequential proton loss electron-transfer (SPLET) process.

The radical-scavenging activities of a series of synthetic xyloketals and related chromanes toward DPPH and ABTS were evaluated by absorption spectrometry. Compound 10 displayed significant antioxidative action with a possible radical-scavenging mechanism by a sequential proton loss electron-transfer (SPLET) process.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Pharmaceutica Sinica B - Volume 3, Issue 5, September 2013, Pages 322–327
نویسندگان
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