کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2484242 1114305 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Toward Carbon Monoxide-Based Therapeutics: Critical Drug Delivery and Developability Issues
ترجمه فارسی عنوان
به سمت درمان های مونوکسید کربن: تحویل مواد انتقادی و مسائل مربوط به توسعه پذیری
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی
Carbon monoxide (CO) is an intrinsic signaling molecule with importance on par with that of nitric oxide. During the past decade, pharmacologic studies have amply demonstrated the therapeutic potential of carbon monoxide. However, such studies were mostly based on CO inhalation and metal-based CO-releasing molecules. The field is now at the stage that a major effort is needed to develop pharmaceutically acceptable forms of CO for delivery via various routes such as oral, injection, infusion, or topical applications. This review examines the state of the art, discusses the existing hurdles to overcome, and proposes developmental strategies necessary to address remaining drug delivery issues.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 2, February 2016, Pages 406-416
نویسندگان
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