کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2484364 | 1114308 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and Cell Imaging of a Near-Infrared Fluorescent Magnetic “CdHgTe-Dextran-Magnetic Layered Double Hydroxide-Fluorouracil” Composite
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کلمات کلیدی
UV/Vis spectroscopy - UV / Vis spectroscopyX-ray diffractometry - اشعه ماوراء بنفشFourier transform infrared - تبدیل فوریه مادون قرمزNear-infrared imaging - تصویربرداری نزدیک به مادون قرمزPhysical characterization - خصوصیات فیزیکیTargeted drug delivery - دارورسانی هدفمندSynthesis - سنتزFluorescence spectroscopy - فوتولومینسانس یا فلوئورسانس یا فسفرسانسNanoparticles - نانوذراتCell culture - کشت سلول
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and Cell Imaging of a Near-Infrared Fluorescent Magnetic “CdHgTe-Dextran-Magnetic Layered Double Hydroxide-Fluorouracil” Composite Synthesis and Cell Imaging of a Near-Infrared Fluorescent Magnetic “CdHgTe-Dextran-Magnetic Layered Double Hydroxide-Fluorouracil” Composite](/preview/png/2484364.png)
چکیده انگلیسی
In this article, a water-soluble near-infrared quantum dots of CdHgTe were prepared and subsequently combined with the drug delivery system “dextran-magnetic layered double hydroxide-fluorouracil” (DMF) to build a new nanostructure platform in form of CdHgTe@DMF, in which the fluorescent probe function of quantum dots and the magnetic targeting transport and slow-release curative effect of DMF were blended availably together. The luminescent property particle size, and internal structure of the composite were characterized using fluorescence spectrophotometer, ultraviolet spectrophotometer, laser particle size distribution, TEM, X-ray diffraction, and Fourier transform infrared. The experimental study on fluorescent tags effect and magnetic targeting performance of the multifunctional platform were performed by fluorescent confocal imaging. The results showed that the CdHgTe could be grafted successfully onto the surface of DMF by electrostatic coupling. The CdHgTe@DMF composite showed super-paramagnetic and photoluminescence property in the near-infrared wavelength range of 575-780 nm. Compared with CdHgTe, the CdHgTe@DMF composite could significantly improve the cell imaging effect, the label intensity increased with the magnetic field intensity, and obeyed the linear relationship Dmean = 1.758 + 0.0075M under the conditions of magnetic field interference. It can be implied that the CdHgTe@DMF may be an effective multifunction tool applying to optical bioimaging and magnetic targeted therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 5, May 2016, Pages 1751-1761
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 5, May 2016, Pages 1751-1761
نویسندگان
XueQin Jin, Min Zhang, GuoJing Gou, Jie Ren,