کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2484494 | 1114313 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Solvates of Dasatinib: Diversity and Isostructurality
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Solvates of Dasatinib: Diversity and Isostructurality Solvates of Dasatinib: Diversity and Isostructurality](/preview/png/2484494.png)
چکیده انگلیسی
A series of dasatinib crystalline forms were obtained, and a hierarchical cluster analysis of their powder X-ray diffraction patterns was performed. The resulting dendrogram implies 3 structural groups. The crystal structures of several solvates representing 2 of these groups were determined. The crystal structure analysis confirms the isostructurality of solvates within structural group I and suggests a correlation between solvent molecule size and trends in crystal structures within this group. In addition, the formation relationships in 2-solvent media between different dasatinib solvate groups were determined. The formation preference of solvates was found to follow the ranking group I > group III > group II.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 4, April 2016, Pages 1489-1495
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 4, April 2016, Pages 1489-1495
نویسندگان
Inese SarceviÄa, Ilze Grante, Sergey Belyakov, Toms Rekis, KÄrlis BÄrziÅÅ¡, Andris ActiÅÅ¡, LiÄna Orola,