کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2484601 1114319 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Measurement of Shrinkage and Cracking in Lyophilized Amorphous Cakes Part 3: Hydrophobic Vials and the Question of Adhesion
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Measurement of Shrinkage and Cracking in Lyophilized Amorphous Cakes Part 3: Hydrophobic Vials and the Question of Adhesion
چکیده انگلیسی
The importance of cake adhesion to the inside vial wall during lyophilization of amorphous trehalose cakes was determined by using hydrophobized vials. The degrees of cake shrinkage and cracking were determined independently by photographic imaging of the cake top surface in a dark cell. Additionally, measurements with microcomputed tomography were performed. Adhesion is found to be a determining factor in both cake shrinkage and cracking. The correlation between cake detachment from the vial inner wall and trehalose concentration indicates that adhesion of the frozen solute phase is a determining factor in shrinkage. The hydrophobized vials give reduced cracking at trehalose concentrations of up to 15%. The reduced wetting of the hydrophobized inside vial wall gives a planar cake topography with a uniform distribution of cracks within the cake.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 6, June 2015, Pages 2040-2046
نویسندگان
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