کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2484639 | 1114321 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development and Application of a Multiroute Physiologically Based Pharmacokinetic Model for Oxytetracycline in Dogs and Humans
ترجمه فارسی عنوان
توسعه و کاربرد یک مدل فارماکوکینتیک مبتنی بر فیزیولوژی چندتایی برای اکسایت تری سیکلین در سگ ها و انسان ها
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کلمات کلیدی
Physiologically based pharmacokinetic (PBPK) modelingTetracycline antibiotics - آنتی بیوتیکهای تتراسیکلینOxytetracycline - اکسی تتراسایکلینIn silico modeling - در مدل سازی سیلیکاDogs - سگ هاPharmacokinetics - فارماکوکینتیکcomputational ADME - محاسباتی ADMEMathematical model - مدل ریاضیDisposition - وضع
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
Oxytetracycline (OTC) is a commonly used tetracycline antibiotic in veterinary and human medicine. To establish a quantitative model for predicting OTC plasma and tissue exposure, a permeability-limited multiroute physiologically based pharmacokinetic model was developed in dogs. The model was calibrated with plasma pharmacokinetic data in beagle dogs following single intravenous (5 mg/kg), oral (100 mg/kg), and intramuscular (20 mg/kg) administrations. The model predicted other available dog data well, including drug concentrations in the liver, kidney, and muscle after repeated exposure, and data in the mixed-breed dog. The model was extrapolated to humans and the human model adequately simulated measured plasma OTC concentrations after intravenous (7.14 mg/kg) and oral exposures (6.67 mg/kg). The dog model was applied to predict 24-h OTC area-under-the-curve after three therapeutic treatments. Results were 27.75, 51.76, and 64.17 μg/mL*h in the plasma, and 120.93, 225.64, and 279.67 μg/mL*h in the kidney for oral (100 mg/kg), intravenous (10 mg/kg), and intramuscular (20 mg/kg) administrations, respectively. This model can be used to predict plasma and tissue concentrations to aid in designing optimal therapeutic regimens with OTC in veterinary, and potentially, human medicine; and as a foundation for scaling to other tetracycline antibiotics and to other animal species.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 1, January 2015, Pages 233-243
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 1, January 2015, Pages 233-243
نویسندگان
Zhoumeng Lin, Mengjie Li, Ronette Gehring, Jim E. Riviere,