کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2484675 | 1114322 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dual Role of Photosensitizer and Carrier Material of Fullerene in Micelles for Chemo-Photodynamic Therapy of Cancer
ترجمه فارسی عنوان
نقش دوگانه فانوسسیون کننده و ماده حامل فولرن در میکل ها برای درمان شیمی درمانی فتودینامیک سرطان
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
Derivatives of fullerene (C60) as photosensitizers have rarely been studied as delivery carrier materials. The focus of this study was to explore the potential advantages of diadduct malonic acidâfullerene (DMAâC60) as delivery carrier materials and combination of chemo-phototherapy of some tumors. In this study, DMAâC60 and docetaxel (DTX) were coentrapped in micelles (MCs) (DMAâC60/DTXâMC). The addition of DMAâC60 could obviously improve static stability and decrease critical MC concentration of DTXâMC without hemolysis. The sustained release of DTX and DMAâC60 could be achieved, following Higuichi and firstâorder model, respectively. DMAâC60 could still produce reactive oxygen species efficiently in HeLa cells after encapsulation in MC. The addition of DMAâC60 under irradiation caused DTXâMC more stronger cytotoxicity, cell cycle changes, and more early apoptotic cells in vitro. More importantly, after intravenous injection, the addition of DMAâC60 in DTXâMC could result in 2.25âfold and 4.57âfold longer mean residence time compared with DTXâMC and Duopafei®, increase drug intratumoral distribution and decrease drug distribution in heart and kidney, and enhance antitumor effect under irradiation without body weight loss. These results suggested tremendous promise of DMAâC60 as carrier materials of MC and significant advantages in combination of chemo-phototherapy of some tumors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 10, October 2014, Pages 3225-3234
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 10, October 2014, Pages 3225-3234
نویسندگان
Xinhong Guo, Rui Ding, Ying Zhang, Ling Ye, Xin Liu, Caiping Chen, Zhenzhong Zhang, Yun Zhang,