کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2484678 | 1114322 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nanocomplexes Based on Amphiphilic Hyaluronic Acid Derivative and Polyethylene Glycol-Lipid for Ginsenoside Rg3 Delivery
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Nanocomplexes Based on Amphiphilic Hyaluronic Acid Derivative and Polyethylene Glycol-Lipid for Ginsenoside Rg3 Delivery Nanocomplexes Based on Amphiphilic Hyaluronic Acid Derivative and Polyethylene Glycol-Lipid for Ginsenoside Rg3 Delivery](/preview/png/2484678.png)
چکیده انگلیسی
Hybrid nanocomplex formulations, based on amphiphilic hyaluronic acid-ceramide (HACE) and lipids, were fabricated for the delivery of 20(S)-ginsenoside Rg 3 [(S)-Rg3]. Nanocomplexes with less than 200Â nm mean diameter, narrow size distribution, spherical shape, and negative zeta potential were prepared. The maintenance of the structural stability of the hybrid nanocomplexes in the blood stream was demonstrated by measuring their particle size in serum. Nanocomplexes based on HACE, phosphatidylcholine (PC), and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-2000] (DSPE-PEG) showed a sustained drug release profile compared with other formulations. Blank nanocomplexes exhibited negligible cytotoxicity within the tested concentration range in A549 human lung adenocarcinoma cells. The cellular uptake efficiency of hybrid nanocomplexes was improved compared with the HACE-based nanoparticles probably because of interactions between lipids and the cellular membrane. The results of a pharmacokinetic study in rats revealed decreased in vivo clearance of (S)-Rg3, especially in the HACE/PC/DSPE-PEG-based hybrid nanocomplex (F3) group. The hybrid nanostructure and the outer PEG chain likely contributed to improve in vivo performance of the F3 group. Thus, these developed hybrid nanocomplexes could serve as good candidates for tumor-targeted delivery of anticancer agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 10, October 2014, Pages 3254-3262
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 10, October 2014, Pages 3254-3262
نویسندگان
Jae-Young Lee, Heejung Yang, In-Soo Yoon, Sang-Bum Kim, Seung-Hak Ko, Jae-Seong Shim, Sang Hyun Sung, Hyun-Jong Cho, Dae-Duk Kim,