کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2484890 1114339 2012 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanostructured lipid carriers as novel ophthalmic delivery system for mangiferin: Improving in vivo ocular bioavailability
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Nanostructured lipid carriers as novel ophthalmic delivery system for mangiferin: Improving in vivo ocular bioavailability
چکیده انگلیسی
The aim of this study was to develop a novel nanostructured lipid carriers (NLCs) system to improve ocular bioavailability of mangiferin (MGN) for the potential treatment of cataract. The physicochemical properties of MGN‐loaded NLC (MGN‐NLC) formulation were characterized by particle size, polydispersity index, zeta potential, entrapment efficiency, drug loading, morphological property, and crystalline state. in vitro characteristics were investigated by drug release from NLC system, physical stability, and corneal permeation through excised rabbit cornea. Moreover, in vivo ocular tolerability was assessed by a modified Draize test and histological microscopy. Preocular retention capability was evaluated by slit‐lamp observation. Pharmacokinetic study in the aqueous humor was performed by microdialysis technique. Transmission electron microscopy depicted spherical and uniform morphology. Differential scanning calorimetry and X‐ray diffractometry displayed imperfect crystalline lattice. The optimized MGN‐NLC formulation exhibited a sustained drug release with 3 months stability and 4.31‐fold increase of in vitro corneal permeation. Furthermore, in vivo studies exhibited a high tolerance in the ocular tissues and prolonged drug retention capacity on the corneal surface. Finally, pharmacokinetic study suggested a 5.69‐fold increase of ocular bioavailability compared with MGN solution (MGN‐SOL). Therefore, NLC system is a promising approach for ocular delivery of MGN. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:3833-3844, 2012
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 10, October 2012, Pages 3833-3844
نویسندگان
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