کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2484926 | 1114340 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and Characterization of Chitosan Hydrogels Containing 5-Aminosalicylic Acid Nanopendents for Colon: Specific Drug Delivery
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and Characterization of Chitosan Hydrogels Containing 5-Aminosalicylic Acid Nanopendents for Colon: Specific Drug Delivery Synthesis and Characterization of Chitosan Hydrogels Containing 5-Aminosalicylic Acid Nanopendents for Colon: Specific Drug Delivery](/preview/png/2484926.png)
چکیده انگلیسی
The main aim of this research was to develop and evaluate a multiparticulate system of Ac-poly(amidoamine)(PAMAM)(G4)-chitosan (CS) hydrogels exploiting pH-sensitive and specific biodegradability properties for colon-targeted delivery of 5-aminosalicylic acid (5-ASA). All formulations were evaluated for particle size, encapsulation efficiency, swellability, and in vitro drug release. The size of the hydrogel was found to nanorange. The integrity of 5-ASA in the release fraction was assessed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The CS-Ac-PAMAM hydrogel was developed based on the modulation of ratio show promise as a system for controlled delivery of drug.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 12, December 2010, Pages 4955-4961
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 12, December 2010, Pages 4955-4961
نویسندگان
Mohammad Reza Saboktakin, Roya M. Tabatabaie, Abel Maharramov, Mohammad Ali Ramazanov,