کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485115 | 1114345 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stabilized Amorphous State of Ibuprofen by CoâSpray Drying With Mesoporous SBAâ15 to Enhance Dissolution Properties
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Stabilized Amorphous State of Ibuprofen by CoâSpray Drying With Mesoporous SBAâ15 to Enhance Dissolution Properties Stabilized Amorphous State of Ibuprofen by CoâSpray Drying With Mesoporous SBAâ15 to Enhance Dissolution Properties](/preview/png/2485115.png)
چکیده انگلیسی
A novel formulation process via coâspray drying ibuprofen (IBU) with mesoporous SBAâ15 submicron particles exhibited excellence in production of stable amorphous IBU with significantly enhanced dissolution rate. With drug loading of IBU/SBAâ15 ratio being 50:50 (w/w) or below, most drug molecules were entrapped inside the straight mesoporous channels via the coâspray drying and the morphology of SBAâ15 submicron particles remained unchanged. IBU confined inside the mesoporous structure was in the amorphous state shown by PXRD and DSC measurements. The amorphous state of IBU in the solid dispersion showed remarkable stability when subject to stress test condition of 40°C/75% RH in open pans for 12 months. The uniform pore walls were believed to prevent the reâcrystallization of the homogeneously dispersed drug molecules inside the mesoporous channels with confined nanospace. The dissolution rate of IBU from the coâsprayâdried solid dispersion was significantly enhanced to achieve a rapid release. Even after the accelerated stability test, the rapid drug release property was well preserved. © 2009 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 99: 1997-2007, 2010
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 4, April 2010, Pages 1997-2007
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 4, April 2010, Pages 1997-2007
نویسندگان
ShouâCang Shen, Wai Kiong Ng, Leonard Chia, YuanâCai Dong, Reginald B.H. Tan,