کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2485198 1114348 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IVIVC in oral absorption for fenofibrate immediate release tablets using a dissolution/permeation system
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
IVIVC in oral absorption for fenofibrate immediate release tablets using a dissolution/permeation system
چکیده انگلیسی
The usefulness of a dissolution/permeation (D/P) system to predict the in vivo performance of solid dosage forms containing the poorly soluble drug, fenofibrate, was studied. Biorelevant dissolution media simulating the fasted and fed state conditions of the human gastrointestinal tract were used in order to simulate the effect of food on the absorption of fenofibrate. Moreover, the results obtained from the D/P system were correlated with pharmacokinetic parameters obtained following in vivo studies in rats. The in vitro parameter (amount permeated in the D/P system) reflected well the in vivo performance in rats in terms of AUC and Cmax of fenofibric acid. This study thus demonstrates the potential of the D/P system as valuable tool for absorption screening of dosage forms for poorly soluble drugs. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:2001-2009, 2009
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 6, June 2009, Pages 2001-2009
نویسندگان
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