کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485208 | 1114348 | 2009 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and evaluation of polymeric coated minitablets as multiple unit gastroretentive floating drug delivery systems for furosemide
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
A gastro retentive floating drug delivery system with multiple-unit minitablets based on gas formation technique was developed for furosemide. The system consists of core units (solid dispersion of furosemide:povidone and other excipients), prepared by direct compression process, which are coated with two successive layers, one of which is an effervescent (sodium bicarbonate) layer and other one an outer polymeric layer of polymethacrylates. The formulations were evaluated for pharmacopoeial quality control tests and all the physical parameters evaluated were within the acceptable limits. Only the system using Eudragit RL30D and combination of them as polymeric layer could float within acceptable time. The time to float decreased as amount of the effervescent agent increased and, when the coating level of polymeric layer decreased. The drug release was controlled and linear with the square root of time. By increasing coating level of polymeric layer decreased the drug release. The rapid floating and the controlled release properties were achieved in this present study. The stability samples showed no significant change in dissolution profiles (f2Â =Â 81). The in vivo gastric residence time was examined by radiograms and it was observed that the units remained in the stomach for about 6Â h. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:2122-2132, 2009
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 6, June 2009, Pages 2122-2132
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 6, June 2009, Pages 2122-2132
نویسندگان
Lingam Meka, Bhaskar Kesavan, Venkatasimhadri Naidu Kalamata, Chandra Mohan Eaga, Suresh Bandari, Venkateswarlu Vobalaboina, Madhusudan Rao Yamsani,