کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485296 | 1114351 | 2011 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
High-throughput screening of PLGA thin films utilizing hydrophobic fluorescent dyes for hydrophobic drug compounds
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
PLGAPolymers - بسپار یا پلیمر Surface analysis - تجزیه و تحلیل سطحDrug delivery - تحویل(رهایش) داروRaman spectroscopy - طیف سنجی رامانhigh-throughput screening - غربالگری بالاFluorescein - فلورسئینThin films - فیلم های نازکScanning electron microscopy - میکروسکوپ الکترونی روبشیPaclitaxel - پاکلی تاکسل
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Hydrophobic, antirestenotic drugs such as paclitaxel (PCTX) and rapamycin are often incorporated into thin film coatings for local delivery using implantable medical devices and polymers such as drug-eluting stents and balloons. Selecting the optimum coating formulation through screening the release profile of these drugs in thin films is time consuming and labor intensive. We describe here a high-throughput assay utilizing three model hydrophobic fluorescent compounds: fluorescein diacetate (FDAc), coumarin-6, and rhodamine 6G that were incorporated into poly(d,l-lactide-co-glycolide) (PLGA) and PLGA-polyethylene glycol films. Raman microscopy determined the hydrophobic fluorescent dye distribution within the PLGA thin films in comparison with that of PCTX. Their subsequent release was screened in a high-throughput assay and directly compared with HPLC quantification of PCTX release. It was observed that PCTX controlled-release kinetics could be mimicked by a hydrophobic dye that had similar octanol-water partition coefficient values and homogeneous dissolution in a PLGA matrix as the drug. In particular, FDAc was found to be the optimal hydrophobic dye at modeling the burst release as well as the total amount of PCTX released over a period of 30 days. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:4317-4329, 2011
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 10, October 2011, Pages 4317-4329
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 10, October 2011, Pages 4317-4329
نویسندگان
Terry W.J. Steele, Charlotte L. Huang, Saranya Kumar, Effendi Widjaja, Freddy Yin Chiang Boey, Joachim S.C. Loo, Subbu S. Venkatraman,