کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485298 | 1114351 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro and in vivo characteristics of celecoxib in situ formed suspensions for intra-articular administration
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In vitro and in vivo characteristics of celecoxib in situ formed suspensions for intra-articular administration In vitro and in vivo characteristics of celecoxib in situ formed suspensions for intra-articular administration](/preview/png/2485298.png)
چکیده انگلیسی
The objective of the present study was to explore the potential of using an in situ suspension forming drug delivery system of celecoxib to provide sustained drug exposure in the joint cavity following intra-articular administration. In vitro, precipitates were formed upon addition of a 400 mg/mL solution of celecoxib in polyethylene glycol 400 (PEG 400) to phosphate buffer, pH 7.4, or synovial fluid. The in vitro release profiles of the in situ formed suspensions were characterized by an initial fast release followed by a slower constant flux. In buffer solutions, these fluxes were comparable to those determined for a preformed suspension containing celecoxib in its most stable crystal form despite the in situ formed precipitates contained a mixture of two crystal forms of celecoxib as determined by X-ray powder diffraction. In situ suspension formation in synovial fluid was subject to considerable variation. A relatively high dose of celecoxib, corresponding to 1.25 mg/kg, in the form of PEG 400 solution (400 mg/mL) was injected into the radiocarpal joint in four horses. Celecoxib was present in serum samples taken over 10 days and in the joint tissue (post mortem), strongly indicating that joint sustained celecoxib exposure can be achieved using in situ suspension formation. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:4330-4337, 2011
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 10, October 2011, Pages 4330-4337
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 10, October 2011, Pages 4330-4337
نویسندگان
Susan Weng Larsen, Anna Buus Frost, Jesper Ãstergaard, Maj Halling Thomsen, Stine Jacobsen, Christian Skonberg, Steen Honoré Hansen, Henrik Elvang Jensen, Claus Larsen,