کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2485328 1114352 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Compaction of Pharmaceutical Tablets with Different Polymer Matrices Studied by FTIR Imaging and X-Ray Microtomography
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Compaction of Pharmaceutical Tablets with Different Polymer Matrices Studied by FTIR Imaging and X-Ray Microtomography
چکیده انگلیسی
Water soluble polymers are often used in tablet compaction for their desirable compaction and dissolution properties. ATR-FTIR spectroscopic imaging has been used to analyze in situ the spatial distribution of different components in tablets with different compositions. Caffeine tablets made of three different polymer matrices, microcrystalline cellulose, hydroxypropyl methylcellulose (HPMC) and lactose, were investigated. It was found that the distribution of caffeine is strongly affected by the composition of polymer matrix used in the tablet. X-ray tomography was used to analyze the caffeine distribution as a complementary technique. The results obtained were compared to the ATR-FTIR spectroscopic images.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 10, October 2008, Pages 4269-4277
نویسندگان
, , , ,