کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485328 | 1114352 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Compaction of Pharmaceutical Tablets with Different Polymer Matrices Studied by FTIR Imaging and X-Ray Microtomography
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
Water soluble polymers are often used in tablet compaction for their desirable compaction and dissolution properties. ATR-FTIR spectroscopic imaging has been used to analyze in situ the spatial distribution of different components in tablets with different compositions. Caffeine tablets made of three different polymer matrices, microcrystalline cellulose, hydroxypropyl methylcellulose (HPMC) and lactose, were investigated. It was found that the distribution of caffeine is strongly affected by the composition of polymer matrix used in the tablet. X-ray tomography was used to analyze the caffeine distribution as a complementary technique. The results obtained were compared to the ATR-FTIR spectroscopic images.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 10, October 2008, Pages 4269-4277
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 10, October 2008, Pages 4269-4277
نویسندگان
Patrick Wray, K.L.Andrew Chan, James Kimber, Sergei G. Kazarian,