کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485379 | 1114353 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biocompatibility and In Vivo Tolerability of a New Class of Photoresponsive Alkoxylphenacyl-Based Polycarbonates
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Biocompatibility and In Vivo Tolerability of a New Class of Photoresponsive Alkoxylphenacyl-Based Polycarbonates Biocompatibility and In Vivo Tolerability of a New Class of Photoresponsive Alkoxylphenacyl-Based Polycarbonates](/preview/png/2485379.png)
چکیده انگلیسی
Potential toxicities of chromophoric or polymeric units of most photoresponsive delivery systems have impacted clinical relevance. Herein, we evaluated the biocompatibility and tolerability of alkoxylphenacyl-based polycarbonates (APPs) as a new class of photoresponsive polymers. The polymers were applied as homopolymer or copolymers of polyethylene glycol (10%, w/w) or polycaprolactone (10%, w/w). APP polymers were comparable to poly(lactic-co-glycolic acid) (PLGA) based on cytotoxicity, macrophage activation, and blood compatibility. Data from biodistribution studies in BALB/c mice showed preferential accumulation in kidney and liver. Meanwhile, potential application of APP polymers as immediate or sustained (implants) drug delivery systems indicated that liver and kidney functions were not distorted. Also, plasma levels of tumor necrosis factor-alpha and interleukin-6 were comparable to PLGA-treated mice (p > 0.05). A histological analysis of liver and kidney sections showed no detectable damage for APP polymers. The overall data strongly supported potential consideration of APP polymers as photoresponsive delivery systems especially as implantable or tissue-mimicking photopatterned biomaterials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 102, Issue 5, May 2013, Pages 1650-1660
Journal: Journal of Pharmaceutical Sciences - Volume 102, Issue 5, May 2013, Pages 1650-1660
نویسندگان
Daniel Wehrung, Shuangyi Sun, Elaheh A. Chamsaz, Abraham Joy, Moses O. Oyewumi,