کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485663 | 1114363 | 2008 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Polymeric Enhancers of Mucosal Epithelia Permeability: Synthesis, Transepithelial Penetration-Enhancing Properties, Mechanism of Action, Safety Issues
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کلمات کلیدی
Tight junction - اتصال تنگPolymeric biomaterials - بیومارکرهای پلیمریTransmucosal drug delivery - تحویل داروی ترانس مغذیAbsorption enhancer - تقویت جذبPermeation enhancer - تقویت کننده نفوذTranscellular transport - حمل و نقل بین المللیParacellular transport - حمل و نقل پاراکلولارToxicity - سمی بودنPolymer synthesis - سنتز پلیمرChitosan - کیتوسان
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Polymeric Enhancers of Mucosal Epithelia Permeability: Synthesis, Transepithelial Penetration-Enhancing Properties, Mechanism of Action, Safety Issues Polymeric Enhancers of Mucosal Epithelia Permeability: Synthesis, Transepithelial Penetration-Enhancing Properties, Mechanism of Action, Safety Issues](/preview/png/2485663.png)
چکیده انگلیسی
Transmucosal drug administration across nasal, buccal, and ocular mucosae is noninvasive, eliminates hepatic firstâpass metabolism and harsh environmental conditions, allows rapid onset, and further, mucosal surfaces are readily accessible. Generally, however, hydrophilic drugs, such as peptides and proteins, are poorly permeable across the epithelium, which results in insufficient bioavailability. Therefore, reversible modifications of epithelial barrier structure by permeation enhancers are required. Low molecular weight enhancers generally have physicochemical characteristics favoring their own absorption, whereas polymeric enhancers are not absorbed, and this minimizes the risk of systemic toxicity. The above considerations have warranted the present survey of the studies on polymeric transmucosal penetrationâenhancers that have appeared in the literature during the last decade. Studies on intestinal permeation enhancers are also reviewed as they give information on the mechanism of action and safety of polymers. The synthesis and characterization of polymers, their effectiveness in enhancing the absorption of different drugs across different epithelium types, their mechanism of action and structureâefficacy relationship, and the relevant safety issues are reviewed. The active polymers are classified into: polycations (chitosan and its quaternary ammonium derivatives, polyâLâarginine (polyâLâArg), aminated gelatin), polyanions (Nâcarboxymethyl chitosan, poly(acrylic acid)), and thiolated polymers (carboxymethyl celluloseâcysteine, polycarbophil (PCP)âcysteine, chitosanâthiobutylamidine, chitosanâthioglycolic acid, chitosanâglutathione conjugates).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 5, May 2008, Pages 1652-1680
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 5, May 2008, Pages 1652-1680
نویسندگان
Giacomo Di Colo, Ylenia Zambito, Chiara Zaino,