کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485675 | 1114363 | 2008 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Two-Scale, Three-Phase Theory for Swelling Drug Delivery Systems. Part I: Constitutive Theory
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Two-Scale, Three-Phase Theory for Swelling Drug Delivery Systems. Part I: Constitutive Theory Two-Scale, Three-Phase Theory for Swelling Drug Delivery Systems. Part I: Constitutive Theory](/preview/png/2485675.png)
چکیده انگلیسی
Polymeric carriers used in drug delivery applications, such as hydroxypropyl methylcellulose, that swell significantly upon coming in contact with water (or biological fluid) have been historically difficult to model due to the complex interplay of forces. This article seeks to introduce a thermodynamically consistent framework in which to address such problems. Here, a constitutive theory is developed that is applicable to viscoelastic polymers carrying an initially elastic drug that subsequently dissolves when exposed to a viscous fluid. The theoretical model consists of three phases, the polymer, drug, and fluid. A novel form of Darcy's law is reported that clearly distinguishes between distortional and dilatational forces and accounts for the affect of polymer relaxation on fluid transport. A standard form of Fick's law is also derived.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 5, May 2008, Pages 1878-1903
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 5, May 2008, Pages 1878-1903
نویسندگان
T.F. Weinstein, L.S. Bennethum, J.H. Cushman,