کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485677 | 1114363 | 2008 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Polymeric Micellar Delivery Reduces Kidney Distribution and Nephrotoxic Effects of Cyclosporine A After Multiple Dosing
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Polymeric Micellar Delivery Reduces Kidney Distribution and Nephrotoxic Effects of Cyclosporine A After Multiple Dosing Polymeric Micellar Delivery Reduces Kidney Distribution and Nephrotoxic Effects of Cyclosporine A After Multiple Dosing](/preview/png/2485677.png)
چکیده انگلیسی
The aim of this study was to test the ability of poly(ethylene oxide)âbâpoly(εâcaprolactone) (PEOâbâPCL) micelles to reduce the renal uptake and nephrotoxicity of Cyclosporine A (CyA) after multiple dose administration. Sprague-Dawley rats received CyA i.v. at a dose of 20 mg/kg/day delivered as the commercial formulation (Sandimmune®) or polymeric micellar formulation (PMâCyA). Cremophor EL (the solubilizing agent in Sandimmune®), unloaded PEOâbâPCL micelles, or normal saline were also administered i.v. to control rats. After 7 days, kidney function was assessed through measurement of creatinine (CLcr) and urea clearances, as well as electrolyte concentrations in plasma. Blood and kidney were collected and assayed for CyA. Sandimmune® administration led to decreased CLcr, and increased urea and potassium levels in plasma. In contrast, functional nephrotoxicity with the PMâCyA was not apparent, as the CLcr did not change significantly. The rate of increase in body weight in control rats was 3.1-3.4% per day. Weight gains (1.8% per day) were also noted in the rats given PMâCyA, although the body weight of animals receiving Sandimmune® remained constant. Compared to Sandimmune®, polymeric micelles reduced kidney uptake of CyA by 2.6âfold, and increased CyA levels in blood by 2.1âfold. The results show a potential for PEOâbâPCL micelles in restricting the nephrotoxicity of CyA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 5, May 2008, Pages 1916-1926
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 5, May 2008, Pages 1916-1926
نویسندگان
Hamidreza Montazeri Aliabadi, Sara Elhasi, Dion R. Brocks, Afsaneh Lavasanifar,