کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485879 | 1114369 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Relaxation and Crystallization of Amorphous Carbamazepine Studied by Terahertz Pulsed Spectroscopy
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Relaxation and Crystallization of Amorphous Carbamazepine Studied by Terahertz Pulsed Spectroscopy Relaxation and Crystallization of Amorphous Carbamazepine Studied by Terahertz Pulsed Spectroscopy](/preview/png/2485879.png)
چکیده انگلیسی
At the example of carbamazepine the crystallization of a small organic molecule from its amorphous phase was studied using in situ variable temperature terahertz pulsed spectroscopy (TPS). Even though terahertz spectra of disordered materials in the glassy state exhibit no distinct spectral features we demonstrate subtle changes in the spectra with increasing temperature and discuss the findings in respect to the density of vibrational states. The crystallization leads to distinct spectral features allowing the crystallization and subsequent polymorphic phase transition at higher temperatures to be studied in detail. It is possible to study both relaxation and crystallization processes by variable temperature TPS. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96: 2703-2709, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 10, October 2007, Pages 2703-2709
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 10, October 2007, Pages 2703-2709
نویسندگان
J.Axel Zeitler, Philip F. Taday, Michael Pepper, Thomas Rades,