کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485880 | 1114369 | 2007 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation of Ganciclovir Intestinal Absorption in Presence of Absorption Enhancers
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The purpose of this investigation was to study the influences of absorption enhancers in increasing oral bioavailability of Ganciclovir (GAN) by assessing the transepithelial permeation across cell monolayers in vitro and bioavailability in rats in vivo. The permeation of GAN across Cacoâ2 and MDCK cell monolayers in the absence/presence of dimethylâβâcyclodextrin (DMβCD), chitosan hydrochloride (CH), sodium lauryl sulphate (SLS), and their combinations was studied for a 2âh period. GAN was administered to rats in absence/presence of absorption enhancers and drug contents in plasma were estimated. We found that the apparent permeability coefficient (Papp) of GAN in absence of absorption enhancers (control) were 0.261â±â0.072âÃâ10â6 and 0.486â±â0.063âÃâ10â6 cm/s in Cacoâ2 and MDCK cell monolayers, respectively, whereas in the presence of DMβCD, CH, SLS, and their combinations, Papp of GAN increased by 5â to 25âfold and 7â to 33âfold as compared to control in Cacoâ2 and MDCK cell monolayers, respectively. However, in rats, the maximum enhancement in bioavailability of GAN during coadministration of these absorption enhancers was only fivefold compared to GAN control. To conclude, the absorption enhancersâDMβCD, CH, SLS, and their combinations demonstrated significant improvement in transepithelial permeation and bioavailability of GAN. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96: 2710-2722, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 10, October 2007, Pages 2710-2722
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 10, October 2007, Pages 2710-2722
نویسندگان
Pranav Shah, Viral Jogani, Pushpa Mishra, Anil Kumar Mishra, Tamishraha Bagchi, Ambikanandan Misra,