کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486115 | 1114375 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Controlled Release of Chlorhexidine Diacetate from a Porous Methacrylate System: Supercritical Fluid Assisted Foaming and Impregnation
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Controlled Release of Chlorhexidine Diacetate from a Porous Methacrylate System: Supercritical Fluid Assisted Foaming and Impregnation Controlled Release of Chlorhexidine Diacetate from a Porous Methacrylate System: Supercritical Fluid Assisted Foaming and Impregnation](/preview/png/2486115.png)
چکیده انگلیسی
The release of chlorhexidine diacetate (CX) from a selfâcuring polymeric system based on poly(ethylmethacrylate) and tetrahydrofurfurylmethacrylate (PEM/THFM) was developed in this study. Supercritical fluid assisted impregnation and foaming was employed for preparing porous CXâPEM/THFM drug release system. Xâray diffraction (XRD) and differential scanning calorimetry (DSC) show that the crystallinity of CX significantly decreased after supercritical processing, whilst Raman spectroscopy suggested a hydrogen bonding interaction between the CX and PEM in the product. A UV-Vis dissolution study revealed that the drug release rate is almost as seven times faster in the SCF processed drug delivery system than conventional cured samples. © 2007 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 96:2048-2056, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 8, August 2007, Pages 2048-2056
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 8, August 2007, Pages 2048-2056
نویسندگان
K. Gong, M. Braden, M.P. Patel, I.U. Rehman, Z. Zhang, J.A. Darr,