کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2486125 1114375 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Predicting Human Drug Pharmacokinetics from In Vitro Permeability Using an Absorption-Disposition Model
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Predicting Human Drug Pharmacokinetics from In Vitro Permeability Using an Absorption-Disposition Model
چکیده انگلیسی
The purpose of this research is to simulate the in vivo performance of drugs with a wide range of solubility and permeability characteristics formulated as oral dosage forms. The absorption-disposition model was developed using a number of physiological parameters as well as in vitro permeability data generated with Caco‐2 cells, 2/4/A1 cells, and hexadecane membranes. A total of 13 drugs with varying solubility and permeability properties were examined using the absorption-disposition model to predict their pharmacokinetic profile. The correlation of predicted and experimentally determined AUC and Cmax, as measures of the pharmacokinetic profile, were >0.96 for all permeation techniques examined. The predictive ability of the model is influenced by the type of permeation method employed; 2/4/A1 cell data yielded the highest degree of accuracy in predicting Cmax and AUC values. The absorption-disposition model developed in this work accurately predicts the in vivo performance of a wide range of orally administered drugs with 8 of 9 drugs examined falling within 80-125% of the experimental value of AUC when using 2/4/A1 cells. © 2007 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 96:2161-2170, 2007
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 8, August 2007, Pages 2161-2170
نویسندگان
, , ,