کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2486146 | 1556514 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aerosol Tribocharging and its Relation to the Deposition of Oxis⢠Turbuhaler® in the Electrical Next Generation Impactor
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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![عکس صفحه اول مقاله: Aerosol Tribocharging and its Relation to the Deposition of Oxis⢠Turbuhaler® in the Electrical Next Generation Impactor Aerosol Tribocharging and its Relation to the Deposition of Oxis⢠Turbuhaler® in the Electrical Next Generation Impactor](/preview/png/2486146.png)
چکیده انگلیسی
Although there have been published electrostatic characterisation studies of drugâonly Turbuhaler® and lactose carrier-drug formulations, there has not been an investigation into spheronised agglomerates containing micronised lactose and eformoterol, such as in Oxis® Turbuhaler®. Ten doses of Oxis® (12 µ g eformoterol) were dispersed into an electrical next generation impactor (eNGI) in a single run, and runs were conducted in triplicate to determine the aerosol performance and aerosol charge distribution at flow rates of 30, 60 and 90 L/min. Eformoterol fine particle fraction (FPF) reached a maximum of 50%-60% at 60 and 90 L/min, whereas lactose FPF increased from 31% to 42% when flow rate was increased from 30 to 90 L/min. Specific net charge (C/µ g) within the eNGI stages increased from 30 to 60 L/min, but then decreased at 90 L/min. These results were attributed to the shift in balance between surface charging after interparticle and particle-surface collision (dominant at 30 and 60 L/min) and charge separation after impact fragmentation of agglomerates (dominant at 90 L/min). However, the aerosol charge profiles do not suggest that electrostatic forces play a major role in the deposition of Oxis® Turbuhaler® dry powder formulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 12, December 2011, Pages 5270-5280
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 12, December 2011, Pages 5270-5280
نویسندگان
Susan Hoe, Paul M. Young, Daniela Traini,