کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2486356 1114381 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Monitoring lidocaine single‐crystal dissolution by ultraviolet imaging
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Monitoring lidocaine single‐crystal dissolution by ultraviolet imaging
چکیده انگلیسی
Dissolution critically affects the bioavailability of Biopharmaceutics Classification System class 2 compounds. When unexpected dissolution behaviour occurs, detailed studies using high information content technologies are warranted. In the present study, an evaluation of real‐time ultraviolet (UV) imaging for conducting single‐crystal dissolution studies was performed. Using lidocaine as a model compound, the aim was to develop a setup capable of monitoring and quantifying the dissolution of lidocaine into a phosphate buffer, pH 7.4, under stagnant conditions. A single crystal of lidocaine was placed in the quartz dissolution cell and UV imaging was performed at 254 nm. Spatially and temporally resolved mapping of lidocaine concentration during the dissolution process was achieved from the recorded images. UV imaging facilitated the monitoring of lidocaine concentrations in the dissolution media adjacent to the single crystals. The concentration maps revealed the effects of natural convection due to density gradients on the dissolution process of lidocaine. UV imaging has great potential for in vitro drug dissolution testing. © 2011 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:3405-3410, 2011
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 100, Issue 8, August 2011, Pages 3405-3410
نویسندگان
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