Spray Drying Technique. I: Hardware and Process Parameters

Spray drying is a transformation of feed from a fluid state into a dried particulate form by spraying the feed into a hot drying medium. The main aim of drying by this method in pharmaceutical technology is to obtain dry particles with desired properties. This review presents the hardware and process parameters that affect the properties of the dried product. The atomization devices, drying chambers, air-droplet contact systems, the collection of dried product, auxiliary devices, the conduct of the spray drying process, and the significance of the individual parameters in the drying process, as well as the obtained product, are described and discussed. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:575-586, 2010