کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2486496 1114384 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Terahertz spectroscopy to identify the polymorphs in freeze-dried mannitol
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Terahertz spectroscopy to identify the polymorphs in freeze-dried mannitol
چکیده انگلیسی
We show how terahertz time-domain spectroscopy (THz-TDS) in the range from 0.1 to 7.5 THz can be used to identify the polymorphs of Mannitol, a frequently used excipient in the freeze drying industry. The results are subsequently used to study the effect that different freeze drying techniques have on the formation of these polymorphs. We find that, depending on the freeze-drying technique, the Mannitol either crystallizes in the δ form, or in a mixture of both the δ form and the β form. The results are in agreement with conventional X-ray diffraction measurements used to identify the polymorphs. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:932-940, 2010
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 2, February 2010, Pages 932-940
نویسندگان
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