کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2486717 1114391 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of Phenylbutazone and Poly(Amidoamine) Dendrimers Interactions by a Combination of Solubility, 2D-NOESY NMR, and Isothermal Titration Calorimetry Studies
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Evaluation of Phenylbutazone and Poly(Amidoamine) Dendrimers Interactions by a Combination of Solubility, 2D-NOESY NMR, and Isothermal Titration Calorimetry Studies
چکیده انگلیسی
The interactions between phenylbutazone, a well-established nonsteroidal anti-inflammatory drug, with different generations of poly(amidoamine) (PAMAM) dendrimers, have been investigated by aqueous solubility, two dimensional nuclear Overhauser effect spectroscopy (2D-NOESY) and isothermal titration calorimetry (ITC) studies. Solubility results showed that PAMAM dendrimers significantly enhanced the aqueous solubility of phenylbutazone and the solubilization was much influenced by dendrimer concentration, generation, surface function group and pH value. The 2D-NOESY spectra clearly showed that there were several kinds of cross-peaks from NOE interactions between the protons of phenylbutazone and the protons in interior cavities of both generation 6 and generation 3 PAMAM dendrimers. The solubility, 2D-NOESY results and ITC analysis suggest that encapsulation and electrostatic interaction together caused the solubility enhancement of phenylbutazone. The new techniques such as 2D-NOESY and ITC used in this study are useful tools in investigating the interactions between dendrimers and guest molecules.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 98, Issue 3, March 2009, Pages 1075-1085
نویسندگان
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