کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2486766 1114392 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantitative Evaluation of Mefenamic Acid Polymorphs by Terahertz-Chemometrics
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Quantitative Evaluation of Mefenamic Acid Polymorphs by Terahertz-Chemometrics
چکیده انگلیسی

ABSTRACTThe purpose of the present study is to measure polymorphic content in a bulk powder, mefenamic acid polymorph of pharmaceuticals, as a model drug by THz-spectrometer using frequency-tunable THz wave generators based on difference-frequency generation in gallium phosphate crystals. Mefenamic acid polymorphic forms I and II were obtained by recrystallisation. Eleven standard samples varying a various polymorphic form I content (0–100%) were prepared by physical mixing. After smoothing and area normalising, the THz-spectra of all standard samples showed an isosbestic point at 3.70 THz. After the THz-spectral data sets were arranged into five frequency ranges, and pretreated using various functions, calibration models were calculated by the partial least square regression method. The effect of spectral data management on the chemometric parameters of the calibration models was investigated. The relationship between predicted and actual form I content was the best linear plot. On the regression vector (RV) that corresponded to absorption THz-spectral data, the peak at 1.45 THz was the highest value, and the peak at 2.25 THz was the lowest on RV. THz-spectroscopy with chemometrics would be useful for the quantitative evaluation of mefenamic acid polymorphs in the pharmaceutical industry. This method is expected to provide a rapid and nondestructive quantitative analysis of polymorphs. © 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:4048-4053, 2010

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 99, Issue 9, September 2010, Pages 4048–4053
نویسندگان
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